| 25.09.2021 11:00 | FC Energie Cottbus | - | Hallescher FC | 1 | : | 2 |
| 25.09.2021 11:00 | VfL Wolfsburg | - | Chemnitzer FC | 2 | : | 0 |
| 25.09.2021 13:00 | RasenBallsport Leipzig | - | Hannover 96 | 1 | : | 3 |
| 25.09.2021 13:00 | FC Erzgebirge Aue | - | SG Dynamo Dresden | 0 | : | 2 |
| 25.09.2021 13:00 | Eintracht Braunschweig | - | F.C. Hansa Rostock | 0 | : | 0 |
| 25.09.2021 13:00 | Hertha BSC | - | FC Carl Zeiss Jena | 2 | : | 0 |
| 25.09.2021 15:00 | FC St. Pauli | - | 1. FC Union Berlin | 0 | : | 2 |
| 25.09.2021 15:00 | KSV Holstein Kiel | - | Hamburger SV | 2 | : | 1 |
| 26.09.2021 11:00 | SV Werder Bremen | - | Hertha 03 Zehlendorf | 2 | : | 1 |
Spielfrei: FC Viktoria 1889 Berlin
| Sp. | Pkt. | Tore | Diff. | |||
|---|---|---|---|---|---|---|
| 1 | Hertha BSC | 10 | 30 | 34:2 | 32 | |
| 2 | FC St. Pauli | 10 | 22 | 27:6 | 21 | |
| 3 | VfL Wolfsburg | 10 | 21 | 23:11 | 12 | |
| 4 | Hamburger SV | 9 | 19 | 20:10 | 10 | |
| 5 | Chemnitzer FC | 10 | 19 | 14:14 | 0 | |
| 6 | 1. FC Union Berlin | 10 | 18 | 14:10 | 4 | |
| 7 | Hannover 96 | 9 | 16 | 12:12 | 0 | |
| 8 | SG Dynamo Dresden | 9 | 15 | 18:11 | 7 | |
| 9 | SV Werder Bremen | 9 | 15 | 21:17 | 4 | |
| 10 | RasenBallsport Leipzig | 9 | 13 | 12:13 | -1 | |
| 11 | FC Viktoria 1889 Berlin | 9 | 12 | 13:14 | -1 | |
| 12 | F.C. Hansa Rostock | 10 | 11 | 14:18 | -4 | |
| 13 | KSV Holstein Kiel | 9 | 10 | 13:22 | -9 | |
| 14 | FC Energie Cottbus | 10 | 9 | 11:24 | -13 | |
| 15 | Eintracht Braunschweig | 9 | 8 | 8:15 | -7 | |
| 16 | FC Erzgebirge Aue | 9 | 8 | 6:15 | -9 | |
| 17 | Hertha 03 Zehlendorf | 9 | 6 | 13:19 | -6 | |
| 18 | Hallescher FC | 10 | 5 | 8:35 | -27 | |
| 19 | FC Carl Zeiss Jena | 10 | 4 | 4:17 | -13 |
Hinweis: Tabellenstand ohne vorgezogene Spiele!
| 02.10.2021 11:00 | FC Carl Zeiss Jena | - | VfL Wolfsburg | 1 | : | 1 |
| 02.10.2021 11:00 | Hertha 03 Zehlendorf | - | KSV Holstein Kiel | 2 | : | 0 |
| 02.10.2021 11:00 | F.C. Hansa Rostock | - | SV Werder Bremen | 2 | : | 0 |
| 02.10.2021 12:00 | 1. FC Union Berlin | - | FC Energie Cottbus | 3 | : | 1 |
| 02.10.2021 12:00 | SG Dynamo Dresden | - | RasenBallsport Leipzig | 1 | : | 2 |
| 02.10.2021 13:00 | Hannover 96 | - | FC St. Pauli | 0 | : | 0 |
| 02.10.2021 14:00 | FC Viktoria 1889 Berlin | - | FC Erzgebirge Aue | 1 | : | 0 |
| 02.10.2021 14:00 | Chemnitzer FC | - | Eintracht Braunschweig | 2 | : | 1 |
| 04.12.2021 14:00 | Hallescher FC | - | Hertha BSC | 0 | : | 3 |
Spielfrei: Hamburger SV