| 09.04.2022 11:00 | 1. FC Lokomotive Leipzig | - | SV Dessau 05 | 3 | : | 0 |
| 09.04.2022 12:00 | SC Borea Dresden | - | SSV 07 Schlotheim | 3 | : | 0 |
| 09.04.2022 12:00 | 1. FC Magdeburg | - | SV Empor Berlin | 6 | : | 0 |
| 10.04.2022 12:00 | Füchse Berlin | - | 1. FC Neubrandenburg 04 | 3 | : | 2 |
| 10.04.2022 12:00 | 1. FC Union Berlin II | - | FC Carl Zeiss Jena II | 1 | : | 1 |
| 10.04.2022 12:00 | Tennis Borussia Berlin | - | Hallescher FC II | 7 | : | 1 |
| 10.04.2022 12:00 | FC Mecklenburg Schwerin | - | Hertha BSC II | 1 | : | 2 |
| 13.04.2022 13:00 | SG Dynamo Dresden II | - | SV Babelsberg 03 | 3 | : | 0 |
| 27.04.2022 13:00 | FC Rot-Weiß Erfurt | - | RasenBallsport Leipzig II | 2 | : | 5 |
Spielfrei: FSV Bernau
| Sp. | Pkt. | Tore | Diff. | |||
|---|---|---|---|---|---|---|
| 1 | RasenBallsport Leipzig II | 15 | 40 | 40:16 | 24 | |
| 2 | 1. FC Magdeburg | 15 | 38 | 56:7 | 49 | |
| 3 | Tennis Borussia Berlin | 15 | 32 | 35:14 | 21 | |
| 4 | Hertha BSC II | 15 | 31 | 39:13 | 26 | |
| 5 | SC Borea Dresden | 15 | 27 | 33:23 | 10 | |
| 6 | 1. FC Union Berlin II | 15 | 24 | 32:24 | 8 | |
| 7 | SG Dynamo Dresden II | 16 | 24 | 25:24 | 1 | |
| 8 | Füchse Berlin | 15 | 22 | 22:18 | 4 | |
| 9 | SV Babelsberg 03 | 15 | 22 | 18:16 | 2 | |
| 10 | SV Empor Berlin | 15 | 22 | 22:25 | -3 | |
| 11 | 1. FC Lokomotive Leipzig | 15 | 19 | 23:26 | -3 | |
| 12 | FSV Bernau | 15 | 17 | 35:37 | -2 | |
| 13 | FC Rot-Weiß Erfurt | 15 | 17 | 23:32 | -9 | |
| 14 | FC Mecklenburg Schwerin | 15 | 15 | 24:36 | -12 | |
| 15 | FC Carl Zeiss Jena II | 16 | 13 | 22:37 | -15 | |
| 16 | Hallescher FC II | 15 | 12 | 19:37 | -18 | |
| 17 | SSV 07 Schlotheim | 15 | 12 | 13:39 | -26 | |
| 18 | 1. FC Neubrandenburg 04 | 15 | 11 | 14:37 | -23 | |
| 19 | SV Dessau 05 | 16 | 2 | 8:42 | -34 |
Hinweis: Tabellenstand ohne vorgezogene Spiele!
| 23.04.2022 14:00 | 1. FC Neubrandenburg 04 | - | 1. FC Magdeburg | 0 | : | 8 |
| 24.04.2022 12:00 | SV Empor Berlin | - | Tennis Borussia Berlin | 1 | : | 3 |
| 24.04.2022 12:00 | SV Babelsberg 03 | - | Füchse Berlin | 1 | : | 1 |
| 24.04.2022 12:00 | Hallescher FC II | - | FC Mecklenburg Schwerin | 4 | : | 2 |
| 24.04.2022 12:00 | SSV 07 Schlotheim | - | 1. FC Lokomotive Leipzig | 0 | : | 1 |
| 24.04.2022 12:00 | FSV Bernau | - | SG Dynamo Dresden II | 3 | : | 0 |
| 24.04.2022 12:00 | SV Dessau 05 | - | 1. FC Union Berlin II | 1 | : | 4 |
| 24.04.2022 14:00 | Hertha BSC II | - | FC Rot-Weiß Erfurt | 6 | : | 2 |
| 01.05.2022 12:00 | RasenBallsport Leipzig II | - | SC Borea Dresden | 1 | : | 2 |
Spielfrei: FC Carl Zeiss Jena II